The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.
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megalomaniac -
Someone who has an unnaturally strong wish for power and control.
The dictator showed signs of being a megalomaniac even as a child, the way he bossed everyone around in the schoolyard.
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crackpot -
A slightly strange or foolish person
Wearing mismatched clothing and yelling to nobody in particular, the crackpot was amusing and ignored by the people who passed him by.
adjective
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delirious -
In a disturbed state of mind, often due to illness or fever, leading to confusion and hallucinations.
After three sleepless nights, he was delirious and barely able to speak clearly.
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deranged -
Behaving in an uncontrolled or dangerous way because of mental illness
Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs
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unhinged -
Mentally unbalanced and unstable
Trevor crossed the street when he saw the unhinged person yelling at him.
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crank -
Someone who others think has unusual ideas or behaves strangely
Bill was seen as crank by his friends, because of the way he always spoke of the dangers of eating meat and being vaccinated.
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lunacy -
Stupid or crazy ideas or behavior that is likely to have bad results
When Edwin Hubble suggested in 1922 that most of the little dots in the sky are entire galaxies, most scientists thought that the idea was sheer lunacy.
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berserk -
To behave in a wild and uncontrolled way as a result of something unexpected happening.
When Anne found out that she had lost all her money as a result of stock fraud, she went berserk, running around the house, screaming and breaking dishes.
adjective
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nuts -
Crazy, insane, or stupid, often in a humorous way
Bill's friends thought he was nuts for swimming in the middle of the winter.
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daffy -
Silly, different, strange, and funny
Fred had a twirled mustache and wore an oddly colored suit, but the town's residents simply viewed him as daffy instead of someone to be afraid of.
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weirdo -
A person whose dress or behavior seems strange
The weirdo kept peeking at everyone from behind the bushes.