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writhe - To make continual twisting, squirming movements or contortions of the body

The soccer player writhed in pain on the ground after spraining his ankle.

adjective

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exasperating - Intensely irritating; infuriating

Molly tried to enter the information in the online form, but she found the confusing directions so exasperating that she grabbed her own hair and screamed in frustration.

adjective

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impoverished - Very poor.

We can hardly imagine how impoverished the average person was during the Middle Ages.

noun

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angst - A feeling of deep anxiety or dread, typically an unfocused one about the human condition or the state of the world in general

Edvard Munch's famous painting, "The Scream," is often viewed as an expression of angst in an uncertain world.

adjective

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strenuous - Requiring great effort, energy, or strength, needing vigorous or intense in activity or action.

Hiking up the mountain was a strenuous task, but the view was worth it.

noun

See verb

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burden - something you carry or withstand with much difficulty.

Financial debt can be a huge burden on families.

noun

See verb

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torment - Severe physical or mental suffering

Sufferers of depression must deal with the torment of their own thoughts on a regular basis.

noun

See verb

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exile - The state of being banned or forced to live away from one's native country, often for political reasons.

After the revolution, the king lived in exile in a foreign land.

adjective

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agonizing - Something that causes great physical or mental pain.

After she took the final exam, it was agonizing to her that for a whole week she wouldn't find out the results.

adjective

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afflicted - Suffering from a serious problem, illness, or pain, be it mental or physical.

Many people are afflicted with anxiety in high-pressure situations.

adjective

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humiliated - To feel ashamed after someone embarrasses you in front of others.

When Jim revealed to everyone at the party that Marty hadn't even finished 6th grade, Marty felt humiliated.

noun

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anguish - Severe mental or physical pain or suffering

With her personal and professional life in disarray, Jenny's anguish was often too much for her to bear.