writhe -
To make continual twisting, squirming movements or contortions of the body
The soccer player writhed in pain on the ground after spraining his ankle.
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strenuous -
Requiring great effort, energy, or strength, needing vigorous or intense in activity or action.
Hiking up the mountain was a strenuous task, but the view was worth it.
noun
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plight -
A difficult or unfortunate situation, often one that involves hardship or adversity.
The community came together to help improve the plight of the homeless during the harsh winter months.
adjective
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excruciating -
Intensely painful
Becky had to see the dentist because her toothache was causing her excruciating pain.
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impoverished -
Very poor.
We can hardly imagine how impoverished the average person was during the Middle Ages.
noun
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cramps -
A painful, involuntary contraction of muscles
When Sharon got cramps in her stomach after eating the fish, she suspected that it may have been spoiled.
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throes -
Intense or violent pain and struggle, especially accompanying birth, death, or great change
Samantha experienced agonizing pain during the throes of childbirth.
noun
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exile -
The state of being banned or forced to live away from one's native country, often for political reasons.
After the revolution, the king lived in exile in a foreign land.
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traumatic -
Causing severe and lasting emotional shock and pain.
Bill survived the hurricane at sea on his fishing boat, but it took years for him to recover emotionally from the traumatic experience.
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exasperating -
Intensely irritating; infuriating
Molly tried to enter the information in the online form, but she found the confusing directions so exasperating that she grabbed her own hair and screamed in frustration.