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cantankerous - Bad-tempered, argumentative, and uncooperative

The constant arguing of the cantankerous couple living above Ann always kept her up at night.

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disruptive - Causing problems or preventing something from continuing smoothly.

During class recess, Joey was always disruptive, and the teacher didn't know quite how to handle it.

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crackpot - A slightly strange or foolish person

Wearing mismatched clothing and yelling to nobody in particular, the crackpot was amusing and ignored by the people who passed him by.

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zany - Amusingly unconventional and different

Einstein was unique among geniuses in that he also had a silly and zany side of his personality.

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lunatic - A person who is crazy

Martha was a defensive driver, to be safer with regards to a possible lunatic behind the wheel of another car.

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maniac - Someone who is mentally ill tending towards violent and dangerous behavior.

The film’s villain was portrayed as a ruthless maniac with no regard for human life.

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megalomaniac - Someone who has an unnaturally strong wish for power and control.

The dictator showed signs of being a megalomaniac even as a child, the way he bossed everyone around in the schoolyard.

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deranged - Behaving in an uncontrolled or dangerous way because of mental illness

Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs

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catatonic - Appearing to be in a daze or stupor; unresponsive, not moving or reacting.

His experiment with psychodelics left him in a catatonic state where he showed almost no emotion, and it that took years for him to recover.

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daffy - Silly, different, strange, and funny

Fred had a twirled mustache and wore an oddly colored suit, but the town's residents simply viewed him as daffy instead of someone to be afraid of.

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weirdo - A person whose dress or behavior seems strange

The weirdo kept peeking at everyone from behind the bushes.

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hysterical - Having uncontrolled extreme emotion

When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.