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nuts - Crazy, insane, or stupid, often in a humorous way

Bill's friends thought he was nuts for swimming in the middle of the winter.

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maniac - Someone who is mentally ill tending towards violent and dangerous behavior.

The film’s villain was portrayed as a ruthless maniac with no regard for human life.

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bonkers - Mentally unbalanced, mad and crazy, usually meant humorously

There were many long stretches of time that Joan was cooped up in the house with her kids, and it was making her go bonkers.

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berserk - To behave in a wild and uncontrolled way as a result of something unexpected happening.

When Anne found out that she had lost all her money as a result of stock fraud, she went berserk, running around the house, screaming and breaking dishes.

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daffy - Silly, different, strange, and funny

Fred had a twirled mustache and wore an oddly colored suit, but the town's residents simply viewed him as daffy instead of someone to be afraid of.

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batty - Mad and slightly crazy, usually in a humorous way

The computer system wouldn't let Greg log on or change his password, and it was driving him batty.

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loony - Crazy or silly

The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.

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disruptive - Causing problems or preventing something from continuing smoothly.

During class recess, Joey was always disruptive, and the teacher didn't know quite how to handle it.

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catatonic - Appearing to be in a daze or stupor; unresponsive, not moving or reacting.

His experiment with psychodelics left him in a catatonic state where he showed almost no emotion, and it that took years for him to recover.

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hysterical - Having uncontrolled extreme emotion

When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.

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crackpot - A slightly strange or foolish person

Wearing mismatched clothing and yelling to nobody in particular, the crackpot was amusing and ignored by the people who passed him by.

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megalomaniac - Someone who has an unnaturally strong wish for power and control.

The dictator showed signs of being a megalomaniac even as a child, the way he bossed everyone around in the schoolyard.