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restless - Unwilling or unable to stay still or to be quiet and calm, because of worry or boredome.

On the spring day, the teacher found it hard to keep the class focused, because they seemed restless and kept looking out the window.

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bumpy - Unstable or rough, especially describing a ride or journey.

The bike ride was bumpy because of all the potholes.

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skittish - (of an animal, especially of a horse) excitable or easily scared

Bill's horse was especially skittish around people it didn't know, so they had to be careful when Bill's friend Fred wanted to stroke the horse's mane.

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squeamish - (of a person) easily made to feel sick, faint, or disgusted, especially by unpleasant images, such as the sight of blood

Nico was so squeamish about receiving a flu shot that he broke out into a sweat.

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cramped - Lacking space; uncomfortably small or tight, restricted in movement due to limited space.

We stayed in a cramped little cabin during our camping trip.

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stiff - Difficult to move one's body, often due to tightness or soreness; rigid or not easily bent; firm in structure.

The new shoes were stiff and uncomfortable at first.

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colicky - Having severe abdominal pain, often caused by spasm, obstruction, or distention of any of the hollow viscera, such as the intestines

Pam's crying baby was colicky because of intestinal problems.

verb

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burden - To place a load or responsibility on someone.

Please don’t burden yourself with more work than you can handle.

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sweltering - Uncomfortably hot

In India during the summer, the sweltering heat literally melted the roads.

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stuffy - (of a place) lacking fresh air or ventilation

The office was so stuffy that multiple fans had to be running at all times.

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bothersome - Causing irritation or annoyance.

The teacher found it bothersome that the students were always looking at their cell phones in class.

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leery - Cautious or wary due to realistic suspicions

Ever since she was bitten by a pitbull, Grace was leery of any dog she encountered.